Do 1, 8-naphthyridine sulfonamides possess an inhibitory action against Tet(K) and MsrA efflux pumps in multiresistant Staphylococcus aureus strains?. (October 2020)

• Record Type: Journal Article
• Authors: Oliveira-Tintino, Cícera Datiane de Morais; Tintino, Saulo Relison; Muniz, Débora Feitosa; Barbosa, Cristina Rodrigues dos Santos; Pereira, Raimundo Luiz Silva; Begnini, Iêda Maria; Rebelo, Ricardo Andrade; da Silva, Luiz Everson; Mireski, Sandro Lucio; Nasato, Michele Caroline; Lacowicz Krautler, Maria Isabel; Pereira, Pedro Silvino; Teixeira, Alexandre Magno Rodrigues; de Menezes, Irwin Rose Alencar; Coutinho, Henrique Douglas Melo; Silva, Teresinha Gonçalves da
• Is Part Of: Microbial pathogenesis. Volume 147(2020)
• Publication Date: 2020-10
• Subjects: Antibacterial agent -- Bacterial resistance -- Efflux pump -- Ethidium bromide -- Synergism; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2020.104268
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Naphthyridines represent a class of heterocyclic compounds formed by two condensed aromatic rings. This study aimed to evaluate the antibacterial activity and in vitro inhibition of efflux resistance mechanisms of a series of 1, 8-naphthyridine sulfonamides against strains carrying Tet(K) and MsrA efflux pumps. The efflux pump inhibitory capacity was evaluated by analyzing synergistic effects between 1, 8-naphthyridine sulfonamides and standard antibiotics, as well as ethidium bromide. The following 1, 8-naphthyridines were used: 4-methyl-N-(5-chloro-1, 8-naphthyridin-2-yl)-benzenesulfonamide (Naph 1); 2, 5-Dichloro-N-(5-chloro-1, 8-naphthyridin-2-yl)-benzenesulfonamide (Naph 2); 2, 3, 4-trifluoro-N-(5-chloro-1, 8-naphthyridin-2-yl)benzenesulfonamide (Naph 7); 3-trifluoromethyl-N-(5-chloro-1, 8-naphthyridin-2-yl)-benzenesulfonamide (Naph 9). The 1, 8-naphthyridine sulfonamide derivatives possessed a potential Tet(K) and MsrA efflux pump inhibitory action. Graphical abstract: Image 1