The association of the prothrombin G20210A single-nucleotide polymorphism and the risk of preeclampsia: Systematic review and meta-analysis. (October 2020)

• Record Type: Journal Article
• Authors: Ahmed, Nadir A.; Hamdan, Hamdan Z.; Kamis, Ammar H.; Adam, Ishag
• Is Part Of: European journal of obstetrics, gynecology, and reproductive biology. Volume 253(2020)
• Page Start: 162
• Page End: 169
• Publication Date: 2020-10
• Subjects: Preeclampsia -- Prothrombin -- G20210A single-nucleotide -- Meta-analysis; Obstetrics -- Periodicals; Gynecology -- Periodicals; Reproductive health -- Periodicals; Gynecology -- Periodicals; Obstetrics -- Periodicals; Reproduction -- Periodicals; Obstétrique -- Périodiques; Gynécologie -- Périodiques; Reproduction -- Périodiques; Verloskunde; Gynaecologie; Voortplanting (biologie); Gynecology; Obstetrics; Reproduction; Electronic journals; Periodicals; Electronic journals; 618.05
• DOI: 10.1016/j.ejogrb.2020.08.005
• Languages: English
• ISSNs: 0301-2115

Abstract

Abstract: Objective: We conducted this systematic review and meta-analysis to assess the association between the risk of preeclampsia and the prothrombin G20210A single-nucleotide polymorphism. Study design: We followed the "Preferred Reporting Items for Systematic Reviews and Meta-Analyses" guidelines. Relevant published studies were searched in the data base. The retrieved studies were assessed for quality by using the Modified Newcastle-Ottawa Scale for quality assessment. OpenMeta Analyst software was used for the statistics. Results: Twenty-eight case–control studies enrolling 3821 cases and 4808 controls were included in this systematic review and meta-analysis. We found a significantly increased preeclampsia risk associated with the G20210A polymorphism in three models: allele contrast (A vs. G), OR 2.183, 95 % CI 1.665–2.862; heterozygote (AG vs. GG), OR 2.233, 95 % CI 1.690–2.95; and the dominant model (AA + AG vs. GG) OR 2.240, 95 % CI 1.700–2.950. However, the association was not observed in the homozygote (AA vs. GG) OR 1.310, 95 % CI = 0.632–2.713 r recessive model (AA vs. AG + GG), OR 1.315, 95 % CI = 0.642–2.695. Conclusions: In this meta-analysis, the prothrombin G20210A single-nucleotide polymorphism was associated with an increased risk of preeclampsia.