Atypical Manifestation of DRESS Syndrome. (13th April 2020)

• Record Type: Journal Article
• Authors: Hakim, Christopher; Melitas, Constantine; Nguyen, Eric; Ngo, Kha
• Other Names: Moriwaki Yoshihiro Academic Editor.
• Is Part Of: Case reports in gastrointestinal medicine. Volume 2020(2020)
• Publication Date: 2020-04-13
• Subjects: Gastroenterology -- Case studies -- Periodicals; Digestive organs -- Diseases -- Periodicals; Gastroenterology; Gastrointestinal Diseases; Digestive organs -- Diseases; Gastroenterology; Electronic journals; Periodicals; Case studies; Periodicals; 616.33
• DOI: 10.1155/2020/6863582
• Languages: English
• ISSNs: 2090-6528

Abstract

Abstract : The differential for liver transaminases over 1000 units/liter typically includes liver ischemia, acute viral hepatitis, acetaminophen toxicity, and autoimmune hepatitis. Prompt evaluation is imperative as these etiologies can lead to fulminant liver failure. We present a case of transaminases over 1000 units/liter from an atypical etiology. A 52-year-old male, previously treated with allopurinol for an acute gout flare, presented with persistent fevers. Given that he had taken a "high-risk medication" 2–6 weeks before presentation, subsequently presented with fever, rash, renal impairment, elevated liver enzymes in the thousands, and peripheral eosinophilia, DRESS syndrome secondary to allopurinol was diagnosed.