Unconventional role of lysosomes in phagocytosis. (November 2020)

• Record Type: Journal Article
• Authors: Westman, Johannes; Freeman, Spencer A.; Grinstein, Sergio
• Is Part Of: Cell calcium. Volume 91(2020)
• Publication Date: 2020-11
• Subjects: Phagocytosis -- Calcium -- Lysosome -- Calcineurin -- Dynamin -- Macrophage -- TPC -- TRPML1; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2020.102269
• Languages: English
• ISSNs: 0143-4160

Abstract

Abstract: Lysosomes are generally thought to be required only for the late stages of phagosome maturation, providing the proton pumps (V-ATPases) and hydrolases needed to acidify and degrade the ingested prey. A recent paper by Davis et al. (EMBO J. [2020], doi:10.15252/embj.2019104058) reports the involvement of lysosomes at a much earlier stage, namely in scission of phagosomes from the plasma membrane. Here we analyze these findings, highlighting a number of unexpected observations and unresolved questions.