Lichen planus follicularis tumidus: Immunotyping of the inflammatory infiltrate with focus on plasmacytoid dendritic cells. (23rd July 2020)

• Record Type: Journal Article
• Authors: Saggini, Andrea; Kempf, Werner; Kutzner, Heinz
• Is Part Of: Journal of cutaneous pathology. Volume 47:Number 10(2020)
• Page Start: 923
• Page End: 928
• Publication Date: 2020-07-23
• Subjects: cutaneous lupus erythematosus -- folliculotropic mycosis fungoides -- lichen planus -- milia en plaque -- plasmacytoid dendritic cells; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.13724
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract: Lichen planus follicularis tumidus (LPFT) is a rare clinicopathological variant of lichen planus (LP), clinically presenting with red‐to‐violaceous plaques studded with comedo‐like lesions and keratin‐filled milia‐like cysts. Histopathologically, LPFT is characterized by cystically dilated follicular infundibula in the dermis, surrounded by a dense lichenoid lymphoid infiltrate with an associated interface reaction. We describe the clinicopathological features of an additional case of LPFT, focusing on the number and distribution of CD123(+) TCF4(+) plasmacytoid dendritic cells (pDCs). In our case, pDCs represented approximately 5% of the total inflammatory infiltrate, predominantly exhibiting a lichenoid distribution around the infundibula with no evidence of cluster formation, thus ruling out cutaneous lupus erythematosus. Our report is the first to describe the number and distribution of pDCs in LPFT. The results of our immunohistochemical analysis corroborate the notion that LPFT should be regarded as a rare variant of LP.