Pleiocarpumlignan A, a new dineolignan from Piper pleiocarpum Chang ex Tseng. Issue 19 (1st October 2020)

• Record Type: Journal Article
• Authors: Xu, Wen-Hui; Su, Xiao-Min; Zhang, Xin-Min; Qi, JianHua; Wang, Dawei; Wang, Meng; Liang, Qian
• Is Part Of: Natural product research. Volume 34:Issue 19(2020)
• Page Start: 2809
• Page End: 2815
• Publication Date: 2020-10-01
• Subjects: Piper pleiocarpum Chang ex Tseng -- dineolignan -- neolignan -- cytotoxic activities; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1593167
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The investigation of chemical constituents from the whole plants Piper pleiocarpum Chang ex Tseng resulted in the isolation of one new dineolignan, pleiocarpumlignan A (1 ), along with one known benzoate derivative, trans -2, 3-diacetoxy-1-[(benzoy1oxy)methyl]-cyclohexa-4, 6-diene (2 ), and two known neolignans (3 –4 ) as (±)- trans -dehydrodiisoeugenol (3 ), (7 R, 8 R, 3′ S )-△ 8′ -3′, 6′-dihydro-3′-methoxy-3, 4-methylenedioxy-6′-oxo-8, 3′, 7, O, 4′-lignan (4 ). Their structures were elucidated through extensive spectroscopic analyses including 1D, 2D NMR, HR-ESI-MS, and by comparison with the literature. All compounds (1 –4 ) were firstly isolated from Piper pleiocarpum Chang ex Tseng. The 13 C NMR spectra of 2 were completely assigned for the first time. Cytotoxic activities of these isolated compounds against five human cancer cell lines (including A-549, SMMC-7721, HL-60, MCF-7, and SW-480) were evaluated. Graphical Abstract: