Green approaches for the synthesis of nucleotides, their conjugates and analogues. (1st November 2020)

• Record Type: Journal Article
• Authors: Appy, Lucie; Depaix, Anaïs; Bantreil, Xavier; Lamaty, Frédéric; Peyrottes, Suzanne; Roy, Béatrice
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 195:Number 11(2020)
• Page Start: 930
• Page End: 931
• Publication Date: 2020-11-01
• Subjects: Organophosphorus chemistry -- nucleotides -- dinucleotides -- water chemistry -- mechanochemistry; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2020.1804164
• Languages: English
• ISSNs: 1042-6507

Abstract

Abstract: We have developed original one-pot and protecting group-free approaches, which are also user-friendly and reliable, to synthesize nucleotides and derivatives starting from nucleoside 5'-monophosphates. Both methods present convenient set-up, i.e., non-dry solvents and reagents, substrates in their sodium or acid form, and commercially available and cheap phosphorus reagents as sodium and potassium salts. GRAPHICAL ABSTRACT: