One new sterpurane sesquiterpene from cultures of the basidiomycete Pholiota nameko. Issue 19 (1st October 2020)

• Record Type: Journal Article
• Authors: Niu, Wan-Rong; Guo, Cong-Liang; Lou, Deng-Ji; Li, Rui-Ting; Xiang, Qiao; Zou, Yu-Lin; Cui, Xiu-Ming; Yang, Xiao-Yan
• Is Part Of: Natural product research. Volume 34:Issue 19(2020)
• Page Start: 2754
• Page End: 2759
• Publication Date: 2020-10-01
• Subjects: basidiomycete -- Pholiota nameko -- sesquiterpene -- X-ray -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1586694
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new sterpurane sesquiterpene (1 ), named (3 R, 6 S, 7 S, 8 R, 10 S )-3, 7, 14-trihydroxy-1-sterpurene was isolated from cultures of the basidiomycete Pholiota nameko. The structure of new compound was elucidated by extensive spectroscopic. Additionally, a single crystal X-ray diffraction not only confirmed the structure, but also determined the absolute configuration of the new compound. The compound was evaluated for cytotoxicity against five human cancer cell lines, but no significant cytotoxicity were found (IC50 values > 40 μM). Graphical Abstract: