Defect-engineering a metal–organic framework for CO2 fixation in the synthesis of bioactive oxazolidinones. Issue 19 (25th August 2020)

• Record Type: Journal Article
• Authors: Helal, Aasif; Cordova, Kyle E.; Arafat, Md. Eyasin; Usman, Muhammad; Yamani, Zain H.
• Is Part Of: Inorganic chemistry frontiers. Volume 7:Issue 19(2020)
• Page Start: 3571
• Page End: 3577
• Publication Date: 2020-08-25
• Subjects: Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d0qi00496k
• Languages: English
• ISSNs: 2052-1553

Abstract

Abstract : Three-component, solvent-free cycloaddition of epoxides with aromatic amines and CO2 . Abstract : A novel series of UiO-66 structures with linker-induced defects was synthesized and fully characterized. By using a linker functionalized with a free, dangling alkylamine that replaces the ordinary carboxylate coordinating group, up to 40% of the linkers incorporated within the UiO-66 framework were defect sites. The resulting UiO-66 with linker-induced defects was then demonstrated to be a highly active heterogeneous catalyst. When applied to three-component, solvent-free cycloadditions of epoxides with aromatic amines and CO2 at ambient pressure, a diverse range of bioactive oxazolidinone compounds were isolated in significantly high yields (>90%) with quantitative conversions and regioselectivity. Finally, the catalyst was proven recyclable over 5 consecutive reactions without loss of performance.