Dental and Periodontal Treatment Need after Dental Clearance Is Not Associated with the Outcome of Induction Therapy in Patients with Acute Leukemia: Results of a Retrospective Pilot Study. (21st April 2020)

• Record Type: Journal Article
• Authors: Schmalz, Gerhard; Tulani, Lulzim; Busjan, Rilana; Haak, Rainer; Kottmann, Tanja; Trümper, Lorenz; Hasenkamp, Justin; Ziebolz, Dirk
• Other Names: Grandone Elvira Academic Editor.
• Is Part Of: Advances in hematology. Volume 2020(2020)
• Publication Date: 2020-04-21
• Subjects: Hematology -- Periodicals; Hematologic Diseases; Hematology; Hematology; Periodicals; Periodicals; 616.15
• DOI: 10.1155/2020/6710906
• Languages: English
• ISSNs: 1687-9104

Abstract

Abstract : This retrospective pilot study aimed to detect whether remaining dental/periodontal treatment need and periodontal inflammation after dental clearance would be associated with the initial therapy outcome of adult patients with acute leukemia undergoing induction chemotherapy. Different parameters were assessed from the patients' records: initial blood parameters, blood parameters during initial chemotherapy, leukemia/therapy related complaints, duration of fever, microbiological findings (blood and urine), as well as patients' survival. Dental treatment need was defined as the presence of at least one carious tooth; periodontal treatment need was determined by the presence of probing depth ≥3.5 mm in at least two sextants. To reflect periodontal inflammation, the periodontal inflamed surface area (PISA) was applied. Thirty-nine patients were included. A dental treatment need of 75% and periodontal treatment need of 76% as well as an average PISA of 153.18 ± 158.09 were found. Only two associations were detected: periodontal treatment need was associated with thrombocyte count after 7 days (p = 0.03 ), and PISA was associated with erythrocyte count three days after induction of therapy (p = 0.01 ). It can be concluded that remaining dental and periodontal treatment need as well as periodontal inflammation after dental clearance is not associated with the outcome of induction therapy in adult patients with acute leukemia.