A BRAF V600E Mutation in RET-Negative Medullary Thyroid Cancer. (10th March 2020)

• Record Type: Journal Article
• Authors: Robbins, Richard J.; Thomas, Jessica S.; Osuna, Patricia Mejia; Shakil, Jawairia
• Other Names: Moore Wayne V. Academic Editor.
• Is Part Of: Case reports in endocrinology. Volume 2020(2020)
• Publication Date: 2020-03-10
• Subjects: Endocrinology -- Periodicals; Endocrinology -- Case studies -- Periodicals; Endocrine glands -- Diseases -- Periodicals; Endocrinology; Endocrine System Diseases; Endocrine glands -- Diseases; Endocrinology; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.4
• DOI: 10.1155/2020/7641940
• Languages: English
• ISSNs: 2090-6501

Abstract

Abstract : We report the case of a woman with a sporadic medullary thyroid carcinoma. Genomic analysis found that her tumor did not contain any common RET mutations but did harbor a BRAF V600E mutation. Only one other well-confirmed example of the BRAF V600E mutation has been reported in an MTC patient. We conclude that this common BRAF mutation may independently drive neoplastic transformation of human parafollicular C cells.