Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection. (16th March 2020)

• Record Type: Journal Article
• Authors: Vita, Serena; Zuccalà, Paola; Savinelli, Stefano; Mascia, Claudia; Rossi, Raffaella; Schiavone, Francesco; Marocco, Raffaella; Tieghi, Tiziana; Iannetta, Marco; Nijhawan, Parni; Zingaropoli, Maria Antonella; d'Ettore, Gabriella; Vullo, Vincenzo; Mastroianni, Claudio Maria; Lichtner, Miriam
• Other Names: Holland Martin Academic Editor.
• Is Part Of: Journal of immunology research. Volume 2020(2020)
• Publication Date: 2020-03-16
• Subjects: Immunology -- Periodicals; Immunology -- Research -- Periodicals; 616.07905
• DOI: 10.1155/2020/2781350
• Languages: English
• ISSNs: 2314-8861

Abstract

Abstract : Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.