Anti-HMGCR Specificity of HALIP: A Confirmatory Study. (16th July 2020)

• Record Type: Journal Article
• Authors: Baucells, Andrés; Martínez, Maria Angeles; Alvarado-Cardenas, Marcelo; Mariscal, Anaís; Martinez-Martinez, Laura; Juárez, Cándido; Selva-O'Callaghan, Albert
• Other Names: Sautto Giuseppe A. Academic Editor.
• Is Part Of: Journal of immunology research. Volume 2020(2020)
• Publication Date: 2020-07-16
• Subjects: Immunology -- Periodicals; Immunology -- Research -- Periodicals; 616.07905
• DOI: 10.1155/2020/6292631
• Languages: English
• ISSNs: 2314-8861

Abstract

Abstract : A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies with the HALIP. Human anti-HMGCR antibodies from patients' sera were purified and incubated with rat triple tissue (kidney/stomach/liver). A characteristic HALIP was observed. Additionally, a colocalization assay of human anti-HMGCR antibodies with rabbit polyclonal anti-HMGCR antibodies showed colocalization of both immunofluorescence patterns. This study confirms that the HALIP is due to human anti-HMGCR antibodies.