Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release. (13th July 2020)

• Record Type: Journal Article
• Authors: Alswieleh, Abdullah M.
• Other Names: Rabilloud Franck Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2020(2020)
• Publication Date: 2020-07-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2020/9176257
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : This paper introduces the synthesis of mesoporous silica nanoparticles (MSNs) with three different groups such as amine, thiol, and sulfonic acid, along the internal surface. Trimethyl[3-(trimethoxysilyl)propyl]ammonium chloride was used to modify the external surface of the nanomaterials. Such materials allow control of the drug release from MSN pores. Multifunctional MSNs were loaded with doxycycline (Doxy) to study their capacities and uploading time. The loading profile indicates that sulfonic groups in the internal surface were the most efficient surfaces with a loading capacity of ca. 35% in 90 min in acidic media.