Stability Analysis and Clinic Phenomenon Simulation of a Fractional-Order HBV Infection Model. (19th September 2020)

• Record Type: Journal Article
• Authors: Su, Yongmei; Liu, Sinuo; Song, Shurui; Li, Xiaoke; Ye, Yongan
• Other Names: Guo Songbai Academic Editor.
• Is Part Of: Complexity. Volume 2020(2020)
• Publication Date: 2020-09-19
• Subjects: Chaotic behavior in systems -- Periodicals; Complexity (Philosophy) -- Periodicals; 003
• DOI: 10.1155/2020/8864403
• Languages: English
• ISSNs: 1076-2787

Abstract

Abstract : In this paper, a fractional-order HBV model was set up based on standard mass action incidences and quasisteady assumption. The basic reproductive number R 0 and the cytotoxic T lymphocytes' immune-response reproductive number R 1 were derived. There were three equilibrium points of the model, and stable analysis of each equilibrium point was given with corresponding hypothesis about R 0 or R 1 . Some numerical simulations were also given based on HBeAg clinical data, and the simulation showed that there existed positive logarithmic correlation between the number of infected cells and HBeAg, which was consistent with the clinical facts. The simulation also showed that the clinical individual differences should be reflected by the fractional-order model.