A Cu2O/TBAB-promoted approach to synthesize heteroaromatic 2-amines via one-pot cyclization of aryl isothiocyanates with ortho-substituted amines in water. Issue 37 (16th September 2020)

• Record Type: Journal Article
• Authors: Zhang, Jinli; Chen, Ling; Dong, Yibo; Yang, Jinchen; Wu, Yangjie
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 37(2020)
• Page Start: 7425
• Page End: 7430
• Publication Date: 2020-09-16
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01431a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient approach to synthesize heteroaromatic 2-amines from one-pot desulfurization/dehydrogenative cyclization of aryl isothiocyanates with ortho -substituted amines in water was developed. Abstract : An efficient approach to synthesize heteroaromatic 2-amines from one-pot desulfurization/dehydrogenative cyclization of aryl isothiocyanates with ortho -substituted amines in water was developed. This approach tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to synthesize heteroaromatic 2-amines in moderate to excellent yields. A plausible mechanism was proposed and the role of TBAB and Cu2 O in the present strategy was suggested with the help of ESI mass spectrometry.