Visible-light-induced triple catalysis for a ring-opening cyanation of cyclopropyl ketones. Issue 77 (1st September 2020)

• Record Type: Journal Article
• Authors: Liu, Jing; Liu, Xiao-Peng; Wu, Hong; Wei, Yi; Lu, Fu-Dong; Guo, Kai-Rui; Cheng, Ying; Xiao, Wen-Jing
• Is Part Of: Chemical communications. Volume 56:Issue 77(2020)
• Page Start: 11508
• Page End: 11511
• Publication Date: 2020-09-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc05167e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A ring-opening cyanation of cyclopropyl ketones was developed via a synergistic triple catalysis strategy, providing a wide range of γ-cyanoketones in good reaction efficiencies under mild and eco-friendly conditions. Abstract : An unprecedented triple catalytic, general ring-opening cyanation reaction of cyclopropyl ketones for the construction of γ-cyanoketones is described. The key is to merge photoredox catalysis with Lewis acid catalysis and copper catalysis to enable the selective cleavage of the carbon–carbon bonds and the selective coupling of the generated radical and cyanide anion.