Asymmetric synthesis of benzothiazolopyrimidines with high catalytic efficiency and stereoselectivity under bifunctional phosphonium salt systems. Issue 76 (21st August 2020)

• Record Type: Journal Article
• Authors: Lu, Dongming; Wu, Jia-Hong; Pan, Jianke; Chen, Xue; Ren, Xiaoyu; Wang, Tianli
• Is Part Of: Chemical communications. Volume 56:Issue 76(2020)
• Page Start: 11231
• Page End: 11234
• Publication Date: 2020-08-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc04820h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Bifunctional phosphonium salt-mediated formal [4+2] annulation towards chiral benzothiazolopyrimidine compounds with excellent yields and stereoselectivities. Abstract : An efficient formal [4+2] annulation between 2-benzothiazolimines and allenoates mediated by an amino acid-derived bifunctional phosphonium salt catalyst is developed. This protocol provides a new and facile synthetic approach to create a broad range of isothiourea-based benzothiazolopyrimidine derivatives under mild reaction conditions with high isolated yields and excellent diastereo- and enantioselectivities.