Weak coordinated nitrogen functionality enabled regioselective C–H alkynylation via Pd(ii)/mono-N-protected amino acid catalysis. Issue 76 (21st August 2020)

• Record Type: Journal Article
• Authors: Liu, Bifu; Ouyang, Wensen; Nie, Jianhong; Gao, Yang; Feng, Kejun; Huo, Yanping; Chen, Qian; Li, Xianwei
• Is Part Of: Chemical communications. Volume 56:Issue 76(2020)
• Page Start: 11255
• Page End: 11258
• Publication Date: 2020-08-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc04739b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : By using mono- N -protected amino acid (MPAA) ligand under Pd(ii ) catalysis, regioselective C–H alkynylation of weak coordinated nitrogen functionalities was developed with great efficiency, proceeding via 5, 6 and 7-membered palladacycle intermediates. Abstract : The exploration of weak coordinated amine derivative enabled regioselective C–H functionalization remains challenging due to the elusive achievement of reactivity and selectivity simultaneously. Herein, regioselective C–H alkynylation of various readily transformable nitrogen functionalities was developed with great efficiency, with the assistance of the mono- N -protected amino acid (MPAA) ligand via Pd(ii ) catalysis proceeding via 5, 6 and 7-membered palladacycle intermediates.