An efficient [3+2] annulation for the asymmetric synthesis of densely-functionalized pyrrolidinones and γ-butenolides. Issue 76 (25th August 2020)

• Record Type: Journal Article
• Authors: Qian, Hui; Sun, Song; Zhao, Wanxiang; Sun, Jianwei
• Is Part Of: Chemical communications. Volume 56:Issue 76(2020)
• Page Start: 11295
• Page End: 11298
• Publication Date: 2020-08-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc05188h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Disclosed here is a new [3+2] annulation of siloxy alkynes that provides robust access to highly enantioenriched, densely-substituted pyrrolidinones and γ-butenolides, whose direct synthesis remains challenging. Abstract : Disclosed here is a new [3+2] annulation of siloxy alkynes that provides robust access to highly enantioenriched, densely-substituted pyrrolidinones and γ-butenolides, whose direct synthesis remains challenging. This process also represents a rare asymmetric synthesis of enantrioenriched molecules from siloxy alkynes.