Copper-catalyzed carbonylative synthesis of pyrrolidine-containing amides from γ, δ-unsaturated aromatic oxime esters. Issue 19 (10th September 2020)

• Record Type: Journal Article
• Authors: Zhang, Youcan; Ai, Han-Jun; Wu, Xiao-Feng
• Is Part Of: Organic chemistry frontiers. Volume 7:Issue 19(2020)
• Page Start: 2986
• Page End: 2990
• Publication Date: 2020-09-10
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d0qo00999g
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A new method of low-cost copper-catalyzed carbonylative cyclization for preparing pyrrolidine-containing amides from γ, δ-unsaturated aromatic oxime esters and amines has been described. Abstract : A new method of low-cost copper-catalyzed carbonylative cyclization for preparing pyrrolidine-containing amides from γ, δ-unsaturated aromatic oxime esters and amines has been described. A range of readily available amines were examined, including primary, secondary, and heterocycle amines, giving over 60 examples of targeted N-heterocycle substituted amides with broad functional group tolerance, good chemical selectivity and moderate to excellent yields.