Autocatalytic DNAzyme assembly for amplified intracellular imaging. Issue 77 (17th September 2020)

• Record Type: Journal Article
• Authors: Gong, Keke; Wu, Qiong; Wang, Hong; He, Shizhen; Shang, Jinhua; Wang, Fuan
• Is Part Of: Chemical communications. Volume 56:Issue 77(2020)
• Page Start: 11410
• Page End: 11413
• Publication Date: 2020-09-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc05257d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An autonomously catalytic assembly of an HCR-DNAzyme circuit was facilely constructed for reliable intracellular miR-21 imaging. Abstract : The autocatalytic HCR-DNAzyme platform was constructed as a versatile amplification platform for intracellular microRNA imaging by integrating hybridization chain reaction (HCR) circuit with DNAzyme biocatalysis. The HCR-assembled multifunctional DNAzyme nanowires produce new HCR triggers and numerous transducer DNAzyme amplifier, and thus shows great promise in earlier cancer diagnosis.