Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC. Issue 76 (21st August 2020)

• Record Type: Journal Article
• Authors: Xie, Qian; Wiedmann, Mareike M.; Zhao, Aishan; Pagan, Ivelisse R.; Novick, Richard P.; Suga, Hiroaki; Muir, Tom W.
• Is Part Of: Chemical communications. Volume 56:Issue 76(2020)
• Page Start: 11223
• Page End: 11226
• Publication Date: 2020-08-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc04873a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : By integrating lipid nanodisc and the RaPID technologies, we identified novel peptidic quorum quenchers targeting S. aureus histidine kinase AgrC. Abstract : We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.