An overview of therapeutic anticancer drug monitoring based on surface enhanced (resonance) Raman spectroscopy (SE(R)RS). Issue 19 (14th August 2020)

• Record Type: Journal Article
• Authors: Li, Chunchun; Ye, Ziwei; Xu, Yikai; Bell, Steven E. J.
• Is Part Of: Analyst. Volume 145:Issue 19(2020)
• Page Start: 6211
• Page End: 6221
• Publication Date: 2020-08-14
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/d0an00891e
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : Recent progress in applying surface-enhanced (resonance) Raman spectroscopy as a novel technique for therapeutic monitoring of anticancer drugs are discussed. Abstract : Therapeutic drug monitoring (TDM) is important for many therapeutic regimens and has particular relevance for anticancer drugs which often have serious effects and whose optimum dosage can vary significantly between different patients. Many of the features of surface enhanced (resonance) Raman spectroscopy (SE(R)RS) suggest it should be very suitable for TDM of anticancer drugs and some initial studies which explore the potential of SE(R)RS for TDM of anticancer drugs have been published. This review brings this work together in an attempt to draw some general observations about key aspects of the approach, including the nature of the substrate used, matrix interference effects and factors governing adsorption of the target molecules onto the enhancing surface. There is now sufficient evidence to suggest that none of these pose real difficulties in the context of TDM. However, some issues, particularly the need to carry out multiplex measurements for TDM of combination therapies, have yet to be addressed.