Optical coherence tomography angiography cyclic remodeling of CNV in patients affected by Best macular dystrophy. (2nd September 2020)

• Record Type: Journal Article
• Authors: Murro, Vittoria; Mucciolo, Dario Pasquale; Giorgio, Dario; Sodi, Andrea; Passerini, Ilaria; Cipollini, Francesca; Virgili, Gianni; Giansanti, Fabrizio
• Is Part Of: Ophthalmic genetics. Volume 41:Number 5(2020)
• Page Start: 440
• Page End: 447
• Publication Date: 2020-09-02
• Subjects: OCT-A -- Best -- maculopathy -- vitelliform dystrophy -- CNV -- PDT -- intravitreal injections -- OCT; Eye -- Diseases -- Genetic aspects -- Periodicals; Eye Diseases -- genetics -- Periodicals; Eye Diseases -- in infancy & childhood -- Periodicals; 617.7
• DOI: 10.1080/13816810.2020.1786844
• Languages: English
• ISSNs: 1381-6810

Abstract

ABSTRACT: Purpose: To evaluate the effect of photodynamic therapy and/or intravitreal injections on choroidal neovascularization in treatment-naïve patients affected by Best Macular Dystrophy using OCT-A Materials and Methods: BMD patients with CNV treated using PDT and/or IV were included in the study. All patients underwent a complete ophthalmological examination, OCT and 3 × 3 mm OCT-A. The OCT-A images were analyzed using an open-source software (ImageJ) to assess the CNV membrane area (CNV-MA), the CNV vessel area (CNV-VA), and vessel density (VD) at the follow-ups (3 months after PDT and 1 month after IV). Results: Five eyes of four patients with CNV were included. All eyes received PDT as first-line therapy; 4 eyes underwent more than 1 treatment session: three eyes received 1 IV, whereas one eye had one further PDT. After PDT, the CNV-MA, CNV-VA, and VD quantitative parameters were obtained for four out of five eyes: in three eyes of two patients CNV-MA, CNV-VA, and VD first decreased and then gradually increased during follow-up, whereas in one eye of one patient CNV-MA, CNV-VA, and VD slightly increased. After IV the CNV-MA, CNV-VA, and VD had significantly decreased at the 1-month follow-up in three eyes of three patients. Conclusion: OCT-A is an important tool for the diagnosis of both naïve and fibrotic CNV in BMD patients; it is a non-invasive method for the qualitative and quantitative analysis of neovascular lesions during follow-up. Our results have shown a cyclic remodeling of treated CNV in BMD patients using both PDT and IV.