Intussusception in children aged under two years in India: Retrospective surveillance at nineteen tertiary care hospitals. Issue 43 (7th October 2020)

• Record Type: Journal Article
• Authors: Das, Manoja Kumar; Arora, Narendra Kumar; Gupta, Bini; Sharan, Apoorva; Kameswari, K.; Padmalatha, P.; Prasad, G. Rajendra; Shad, Jimmy; Shyamala, J.; Harish Kumar, S.; Nagender, Yoga; Sharmila, K.; Shad, Rashmi; Garge, Saurabh; Bharadia, Lalit; Gupta, Atul; Goswami, Jayanta K.; Lahiri, Kaushik; Sankhe, Lalit; Mane, Sushant; Patwari, Yogini Prasad; Ajayakumar, M.K.; Santhosh Kumar, A.; Sarangi, Rachita; Tripathy, Bikasha Bihary; Mohapatra, S.S.G.; Sahoo, Subrat Kumar; Kumar, Vijayendra; Kumar, Rakesh; Sarkar, Suman; Sarkar, Ruchirendu; Sarkar, Nihar Ranjan; Wakhlu, Ashish; Ratan, Simmi K.; Dubey, Anand P.; Mohan, Neelam; Luthra, Meera; Vyas, Bhadresh R.; Trivedi, Harsh; Mathai, John; Sam, Cenita J.; Jothilakshmi, K.; Arunachalam, Pavai; Bhat, Javeed Iqbal; Mufti, Gowhar; Charoo, Bashir Ahmad; Jena, Pradeep K.; Debbarma, Sanjib K.; Ghosh, Sunil K.; Aggarwal, Mahesh K.; Haldar, Pradeep; Zuber, Patrick L.F.; Maure, Christine; Bonhoeffer, Jan; Ray, Arindam;
• Is Part Of: Vaccine. Volume 38:Issue 43(2020)
• Page Start: 6849
• Page End: 6857
• Publication Date: 2020-10-07
• Subjects: Intussusception -- Retrospective surveillance -- Children -- Epidemiology -- India; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2020.04.059
• Languages: English
• ISSNs: 0264-410X

Abstract

Abstract: Objective: Intussusception has been linked with rotavirus vaccine (RVV) as a rare adverse reaction. In view of limited background data on intussusception in India and in preparation for RVV introduction, a surveillance network was established to document the epidemiology of intussusception cases in Indian children. Methods: Intussusception in children 2–23 months were documented at 19 nationally representative sentinel hospitals through a retrospective surveillance for 69 months (July 2010 to March 2016). For each case clinical, hospital course, treatment and outcome data were collected. Results: Among the 1588 intussusception cases, 54.5% were from South India and 66.3% were boys. The median age was 8 months (IQR 6, 12) with 34.6% aged 2–6 months. Seasonal variation with higher cases were documented during March-June period. The most common symptoms and signs were vomiting (63.4%), bloody stool (49.1%), abdominal pain (46.9%) and excessive crying (42.8%). The classical triad (vomiting, abdominal pain, and blood in stools) was observed in 25.6% cases. 96.4% cases were diagnosed by ultrasound with ileocolic location as the commonest (85.3%). Management was done by reduction (50.8%) and surgery (41.1%) and only 1% of the patients' died. 91.1% cases met Brighton criteria level 1 and 3.3% Level 2. Between 2010 and 2015, the case load and case ratio increased across all regions. Conclusion: Intussusception cases have occurred in children across all parts of the country, with low case fatality in the settings studied. The progressive rise cases could indicate an increasing awareness and availability of diagnostic facilities.