Brain-behavioral adaptability predicts response to cognitive behavioral therapy for emotional disorders: A person-centered event-related potential study. (August 2020)

• Record Type: Journal Article
• Authors: Stange, Jonathan P.; MacNamara, Annmarie; Kennedy, Amy E.; Hajcak, Greg; Phan, K. Luan; Klumpp, Heide
• Is Part Of: Neuropsychologia. Volume 145(2020)
• Publication Date: 2020-08
• Subjects: Late positive potential -- Event-related potential -- Attention -- Anxiety -- Depression -- CBT; Neuropsychology -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Neuropsychologie -- Périodiques; Neuropsychology; Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.neuropsychologia.2017.06.027
• Languages: English
• ISSNs: 0028-3932

Abstract

Abstract: Single-trial-level analyses afford the ability to link neural indices of elaborative attention (such as the late positive potential [LPP], an event-related potential) with downstream markers of attentional processing (such as reaction time [RT]). This approach can provide useful information about individual differences in information processing, such as the ability to adapt behavior based on attentional demands ("brain-behavioral adaptability"). Anxiety and depression are associated with maladaptive information processing implicating aberrant cognition-emotion interactions, but whether brain-behavioral adaptability predicts response to psychotherapy is not known. We used a novel person-centered, trial-level analysis approach to link neural indices of stimulus processing to behavioral responses and to predict treatment outcome. Thirty-nine patients with anxiety and/or depression received 12 weeks of cognitive behavioral therapy (CBT). Prior to treatment, patients performed a speeded reaction-time task involving briefly-presented pairs of aversive and neutral pictures while electroencephalography was recorded. Multilevel modeling demonstrated that larger LPPs predicted slower responses on subsequent trials, suggesting that increased attention to the task-irrelevant nature of pictures interfered with reaction time on subsequent trials. Whereas using LPP and RT averages did not distinguish CBT responders from nonresponders, in trial-level analyses individuals who demonstrated greater ability to benefit behaviorally (i.e., faster RT) from smaller LPPs on the previous trial (greater brain-behavioral adaptability) were more likely to respond to treatment and showed greater improvements in depressive symptoms. These results highlight the utility of trial-level analyses to elucidate variability in within-subjects, brain-behavioral attentional coupling in the context of emotion processing, in predicting response to CBT for emotional disorders. Highlights: We used a novel person-centered, trial-level analysis approach among adults receiving CBT for anxiety or depression. Attention to the task-irrelevant nature of pictures was indexed by the late positive potential (LPP). We linked neural indices of stimulus processing (the LPP) to behavioral responses (reaction time). Individuals with greater brain-behavioral adaptability were more likely to respond to CBT. Trial-level analyses elucidate variability in within-subjects, brain-behavioral attentional coupling in emotional contexts.