Health-related quality of life in curatively-treated patients with esophageal or gastric cancer: A systematic review and meta-analysis. (October 2020)

• Record Type: Journal Article
• Authors: van den Boorn, Héctor G.; Stroes, Charlotte I.; Zwinderman, Aeilko H.; Eshuis, Wietse J.; Hulshof, Maarten C.C.M.; van Etten-Jamaludin, Faridi S.; Sprangers, Mirjam A.G.; van Laarhoven, Hanneke W.M.
• Is Part Of: Critical reviews in oncology/hematology. Volume 154(2020)
• Publication Date: 2020-10
• Subjects: dCRT definitive chemoradiotherapy -- EORTC European Organisation for Research and Treatment of Cancer -- FACT-E Functional Assessment of Cancer Therapy Scale-Esophageal Cancer -- FACT-HN Functional Assessment of Cancer Therapy Scale-Head and Neck Cancer -- GHS Global Health Status -- HRQoL Health-related Quality of Life -- MOS-SF20 Medical Outcomes Study Short-Form General Healthy Survey-20 -- MSCEH Minimum Standard Checklist for Evaluating HRQoL Outcomes -- nC(R)T neoadjuvant chemo(radio)therapy -- NOQAS Newcastle-Ottawa Quality Assessment Scale -- PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses -- PROM Patient-reported Outcome Measure -- QLQ-C30 Quality of Life Questionnaire Cancer-30 -- QLQ-OC25 Quality of Life Questionnaire Oesophago-gastric Junction or Stomach- -- QLQ-OES18 Quality of Life Questionnaire-Esophagus 18 -- QLQ-OES24 Quality of Life Questionnaire-Esophagus 24 -- QLQ-STO22 Quality of Life Questionnaire-Stomach 22 -- RSCL Rotterdam Symptom Checklist; Esophageal cancer -- Gastric cancer -- Curative treatment -- Health-related quality of life -- Patient-reported outcome -- Quality-of-Life questionnaire; Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2020.103069
• Languages: English
• ISSNs: 1040-8428

Abstract

Highlights: Short-term HRQoL differences are seen between curative treatments in esophageal cancer. No long-term differences in HRQoL are seen with curative treatments in esophageal cancer. Esophagectomy, but not gastrectomy, has a clinically relevant impact on HRQoL. There is a high need for more high-quality HRQoL studies. Abstract: Surgery and chemoradiotherapy can potentially cure esophageal and gastric cancer patients, although they may impact health-related quality of life (HRQoL). We aim to systemically review and meta-analyze literature to determine the effect of curative treatments on HRQoL in esophageal and gastric cancer.— A systematic search was performed identifying studies assessing HRQoL. Meta-analyses were performed on baseline and subsequent time-points.— From the 6067 articles retrieved, 49 studies were included (61 % low quality). Meta-analyses showed short-term HRQoL differences between esophageal cancer patients receiving definitive chemoradiotherapy (dCRT), neoadjuvant chemo(radio)therapy (nC(R)T), or surgery alone ( p < 0.001), with better HRQoL with nC(R)T and surgery compared to dCRT. Over the course of 12 months, no HRQoL difference was identified between treatments in esophageal cancer ( p = 0.633). Esophagectomy, but not gastrectomy, resulted in a clinically relevant decline in HRQoL. No long-term HRQoL differences were identified between curative treatments in esophageal and gastric cancer. More high-quality HRQoL studies are warranted.