Association between family history of lung cancer and lung cancer risk: a systematic review and meta-analysis. (October 2020)

• Record Type: Journal Article
• Authors: Ang, Lina; Chan, Cheryl Pui Yi; Yau, Wai-Ping; Seow, Wei Jie
• Is Part Of: Lung cancer. Volume 148(2020)
• Page Start: 129
• Page End: 137
• Publication Date: 2020-10
• Subjects: Family history -- Lung cancer -- Meta-analysis; Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2020.08.012
• Languages: English
• ISSNs: 0169-5002

Abstract

Highlights: Genetic and environmental factors contribute to familial risk of lung cancer. Asians have higher familial risk of lung cancer as compared to non-Asians. Asians have higher familial risk of squamous cell carcinoma. Females and never-smokers in Asia have higher familial risk of lung cancer. Abstract: Background: Familial risk of lung cancer has been widely studied but the effects of sociodemographic factors and geographical regions are largely unknown. Methods: PubMed and Embase were systematically searched until 1 st October 2019. A total of 84 articles were identified and (19 cohort and 66 case control studies) included in this systematic review and meta-analysis. Pooled summary estimates and 95% confidence intervals were estimated, and the analysis was stratified by sociodemographic factors and geographical regions. Results: Geographical regions, sex, age of proband, smoking status, type of first-degree relatives, number of affected relatives, and early onset of lung cancer in affected relatives were significant determinants of familial risk of lung cancer. Higher risk of familial lung cancer was found among Asians as compared to non-Asians, younger individuals (age≤50) as compared with older individuals (age>50), individuals with ≥2 affected relatives as compared with individuals with one affected relative, ever-smokers as compared with never-smokers, Asian females as compared with Western females, and never-smokers in Asia as compared with never-smokers in the West. Conclusions: Familial risk of lung cancer is influenced by both genetic and environmental factors. Future studies should control for environmental factors such as air pollution and environmental tobacco smoke which are prevalent in Asia.