The Occurrence of Richter's Syndrome during Treatment with Obinutuzumab and Chlorambucil. (16th July 2020)

• Record Type: Journal Article
• Authors: Ng, Teng Fong; Carnley, Benedict; Green, Celia; Spagnolo, Dominic; Leahy, Michael F.
• Other Names: Tauro Sudhir Academic Editor.
• Is Part Of: Case reports in hematology. Volume 2020(2020)
• Publication Date: 2020-07-16
• Subjects: Hematology -- Periodicals; Hematology -- Case studies -- Periodicals; Blood -- Diseases -- Periodicals; Hematology; Hematologic Diseases; Blood -- Diseases; Hematology; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.15
• DOI: 10.1155/2020/8363427
• Languages: English
• ISSNs: 2090-6560

Abstract

Abstract : Chronic lymphocytic leukaemia is a slow-growing leukaemia of developing B-lymphocytes, which may transform to an aggressive lymphoma known as Richter's syndrome. While Richter's syndrome can present in untreated or relapsed-refractory cases, it may occur upon the commencement of less intensity treatment regimens. We present a case of Richter's syndrome following treatment with chlorambucil and obinutuzumab and review of available literature on the topic.