Atypical Hemolytic Uremic Syndrome following Acute Type A Aortic Dissection. (4th March 2020)

• Record Type: Journal Article
• Authors: Ikushima, Eigo; Hisahara, Manabu; Nishijima, Takuya; Uchiyama, Hikaru; Onzuka, Tatsushi; Ochiai, Yoshie; Muta, Tsuyoshi; Tokunaga, Shigehiko
• Other Names: Kyrtsonis Marie-Christine Academic Editor.
• Is Part Of: Case reports in hematology. Volume 2020(2020)
• Publication Date: 2020-03-04
• Subjects: Hematology -- Periodicals; Hematology -- Case studies -- Periodicals; Blood -- Diseases -- Periodicals; Hematology; Hematologic Diseases; Blood -- Diseases; Hematology; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.15
• DOI: 10.1155/2020/2467953
• Languages: English
• ISSNs: 2090-6560

Abstract

Abstract : Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA)-related disease that manifests as a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI) and is caused by uncontrolled activation of the complement system. We report the case of a 61-year-old woman with acute type A aortic dissection that subsequently developed into aHUS. The hematologic disorders underlying aHUS improved after treatment with the complement inhibitor eculizumab. It is important to consider aHUS when a patient clinically develops a triad of microangiopathic hemolytic anemia, thrombocytopenia, and an increasing creatinine level following cardiovascular surgery.