Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain. (4th September 2020)

• Record Type: Journal Article
• Authors: Schirmer, Lucas; Hoornaert, Chloé; Le Blon, Debbie; Eigel, Dimitri; Neto, Catia; Gumbleton, Mark; Welzel, Petra B.; Rosser, Anne E.; Werner, Carsten; Ponsaerts, Peter; Newland, Ben
• Is Part Of: Biomaterials science. Volume 8:Number 18(2020)
• Page Start: 4997
• Page End: 5004
• Publication Date: 2020-09-04
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d0bm01249a
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : The anti-inflammatory cytokine IL-13 can be loaded and released from heparin-based cryogel biomaterials for sustained delivery to the brain. Abstract : Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.