The photo-/thermo-chromism of spiropyran in alkanes as a temperature abuse indicator in the cold chain of vaccines. (10th August 2020)

• Record Type: Journal Article
• Authors: Gao, Mei; Lian, Chaofan; Xing, Rang; Wang, Jie; Wang, Xuefei; Tian, Zhiyuan
• Is Part Of: New journal of chemistry. Volume 44:Number 36(2020)
• Page Start: 15350
• Page End: 15353
• Publication Date: 2020-08-10
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj02975k
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Color change related to the phase change of spiropyran–merocyanine system can indicate temperature changes in vaccine transportation. Abstract : The optimal storage temperature for vaccines ranges from 2 °C to 8 °C. Electronic thermometers can provide real-time and remote temperature monitoring but are not applicable for individual packages. However, it is known that few alkanes have melting points in this range. The photo-induced conversion of colorless spiropyran to blue merocyanine can be thermally reversed, resulting in decoloration. By dispersing spiropyran in a mixture of n -tetradecane and n -pentadecane with the melting point of 8 °C, an accurate and low-cost thermochromism indicator to record temperature abuse has been designed. The results showed that the thin label based on this system has taken a permanent decoloration within 10 min of the temperature exceeding 8 °C.