A novel approach to photoelectrochemical immunoassay for procalcitonin on the basis of SnS2/CdS. (1st September 2020)

• Record Type: Journal Article
• Authors: Wang, Mengdi; Liu, Xuejing; Jia, Hongying; Li, Yuyang; Ren, Xing; Wu, Dan; Wang, Huan; Wei, Qin; Ju, Huangxian
• Is Part Of: New journal of chemistry. Volume 44:Number 35(2020)
• Page Start: 15281
• Page End: 15288
• Publication Date: 2020-09-01
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj02764b
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A label-free photoelectrochemical (PEC) immunoassay system based on the one-step synthesis of SnS2 /CdS nanocomposites is successfully constructed for sensitively analyzing procalcitonin (PCT). Abstract : A label-free photoelectrochemical (PEC) immunoassay system based on the one-step synthesis of SnS2 /CdS nanocomposites is successfully constructed for sensitively analyzing procalcitonin (PCT). The one-step synthesis of SnS2 /CdS enables the rapid construction of an immunoassay system and avoids the waste of energy. In the constructed immunoassay system, CdS as a sensitizer for PCT analysis not only enhances the light absorption of SnS2 as a photocurrent generator but also can accelerate the separation of photosensitive electrons and holes by forming a heterostructure. Under optimum conditions, the energy-saving assay platform based on the enhancement photocurrent response of SnS2 /CdS nanocomposites exhibited an excellent performance in analyzing a series of PCTs with different concentrations in a wide linear range of 0.5 pg mL −1 to 100 ng mL −1 and the detection limit was 0.17 pg mL −1 . In view of the advantages of good selectivity, high sensitivity, and facile preparation procedure, the PEC immunoassay is expected to be a promising analytical platform for rapid analysis of PCT and other biomarkers in clinical medical samples.