Continuous Flow Organophosphorus Chemistry. Issue 33 (8th June 2020)

• Record Type: Journal Article
• Authors: Morodo, Romain; Bianchi, Pauline; Monbaliu, Jean‐Christophe M.
• Is Part Of: European journal of organic chemistry. Issue 33(2020)
• Page Start: 5236
• Page End: 5277
• Publication Date: 2020-06-08
• Subjects: Continuous Flow Chemistry -- Flow reactors -- Microwave chemistry -- Organophosphorus Compounds -- Wittig reactions; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202000430
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : Organophosphorus derivatives are widespread compounds that chemists find from the bench to the plant, with numerous daily life applications. Besides their common utility for a wide range of notorious reactions such as the Wittig and Horner‐Wadsworth‐Emmons olefinations, the Arbuzov reaction, the Staudinger reaction, the Mitsunobu reaction as well as ligands for a large variety of organometallic complexes, organophosphorus compounds have also found numerous applications as active pharmaceutical ingredients and agrochemicals. Some organophosphorus derivatives are also infamously known as Chemical Warfare Agents. Within the context of generalized adoption of new process technologies in the Chemistry Toolbox, this review intends to give an update on the most recent and significant advances in continuous flow organophosphorus chemistry. Selected examples in methodology, total synthesis and for the preparation of industrially relevant targets are discussed for illustrating the assets of flow chemistry. Abstract : With applications ranging from common laboratory reagents to agrochemical blockbusters, organophosphorus compounds are central to organic chemistry. Flow chemistry and related technologies have opened new perspectives in the many areas of organic chemistry, from methodology to total synthesis in R&D and production, regardless of the final potential industrial application. This review gives an overview of the most recent and significant advances in continuous flow organophosphorus chemistry.