Acute effects of e‐cigarette vaping on pulmonary function and airway inflammation in healthy individuals and in patients with asthma. Issue 10 (2nd April 2020)

• Record Type: Journal Article
• Authors: Kotoulas, Serafeim‐Chrysovalantis; Pataka, Athanasia; Domvri, Kalliopi; Spyratos, Dionisios; Katsaounou, Paraskevi; Porpodis, Konstantinos; Fouka, Evangelia; Markopoulou, Aikaterini; Passa‐Fekete, Katalin; Grigoriou, Ioanna; Kontakiotis, Theodoros; Argyropoulou, Paraskevi; Papakosta, Despoina
• Is Part Of: Respirology. Volume 25:Issue 10(2020)
• Page Start: 1037
• Page End: 1045
• Publication Date: 2020-04-02
• Subjects: airway inflammation -- asthma -- e‐cigarette -- impulse oscillometry system -- pulmonary function tests; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 612.2
• DOI: 10.1111/resp.13806
• Languages: English
• ISSNs: 1323-7799

Abstract

ABSTRACT: Background and objective: The acute effects of e‐cigarettes have not been scientifically demonstrated yet. The aim of this study was to assess the acute changes in pulmonary function and airway inflammation in patients with asthma after vaping one e‐cigarette. Methods: Twenty‐five smokers suffering from stable moderate asthma according to GINA guidelines with no other comorbidities and 25 healthy smokers matched with the baseline characteristics of the asthmatic patients were recruited. PFT, IOS, FeNO and EBC were performed before and after vaping one e‐cigarette with nicotine. pH and concentrations of IL‐1β, IL‐4, IL‐5, IL‐6, IL‐8, IL‐10, IL‐13, IL‐17A, TNF‐α, ISO8 and LTB4 were measured in EBC. Results: FFEV1/FVC ratio and PEF were reduced in asthmatic patients after e‐cigarette. Z5Hz and R5Hz, R10Hz and R20Hz increased in both groups. FeNO and EBC pH increased by 3.60 ppb ( P = 0.001) and 0.15 ( P = 0.014) in asthmatic patients after e‐cigarette, whereas they decreased in control group by 3.28 ppb ( P < 0.001) and 0.12 ( P = 0.064), respectively. The concentrations of IL‐10, TNF‐α and ISO8 in EBC increased in asthmatic patients after e‐cigarette and the changes in concentrations of IL‐1β and IL‐4 differed significantly between the two groups. Conclusion: E‐cigarette vaping resulted in acute alteration of both pulmonary function and airway inflammation in stable moderate asthmatic patients. Abstract : The e‐cigarette is rapidly gaining ground on tobacco cigarettes and is a hot topic worldwide, but its safety has not been scientifically proved. This is the first study that investigates the acute effects of e‐cigarettes on both lung function and airway inflammation in asthmatic patients. See related Editorial