Tunable Synthesis of Mesoporous Prussian Blue@Calcium Phosphate Nanoparticles for Synergic Chemo‐Photothermal Cancer Therapy. Issue 35 (15th September 2020)

• Record Type: Journal Article
• Authors: Yu, Baohui; Wang, Chungang
• Is Part Of: ChemistrySelect. Volume 5:Issue 35(2020)
• Page Start: 10841
• Page End: 10847
• Publication Date: 2020-09-15
• Subjects: drug delivery -- nanoparticles -- cancer -- mesoporous materials -- synthesis design; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202001234
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A facile and mild strategy to prepare the mesoporous prussian blue@calcium phosphate core‐shell nanoparticles (M‐PB@CaP core‐shell NPs) composed with a MCaP shell and a MPB core is reported. The obtained NPs exhibited strong absorption in the near infrared (NIR) region and possessed an excellent photothermal efficiency of 26 % resulting from the PB core. The mesoporous structure of PB, CaP and the appearance of PAA in the M‐PB@CaP core‐shell NPs are greatly favorable for the ultrahigh doxorubicin (DOX) loading capability (1 mg DOX/mg NPs) of the NPs. When the DOX‐loaded M‐PB@CaP core‐shell NPs were exposed to NIR irradiation, a burst‐like drug release occurs on account of the heat produced by the M‐PB@CaP core‐shell NPs. These results indicate that the obtained NPs could employ as pH/NIR dual‐responsive drug delivery systems for synergistic chemo‐photothermal therapy of cancer cells. Abstract : A facile and mild strategy to prepare the mesoporous prussian blue@calcium phosphate core‐shell nanoparticles (M‐PB@CaP core‐shell NPs) is reported. The obtained NPs exhibited strong absorption in the near infrared (NIR) region and possessed an excellent photothermal efficiency resulting from the PB core. The DOX‐loaded NPs exhibit superior cancer cell ablation ability under the irradiation of NIR laser. All the results demonstrate that the M‐PB@CaP core‐shell NPs have great potential for synergistic chemo‐photothermal therapy of cancer cells.