Palladium/Norbornene‐Catalyzed Sequential ortho‐Acylation and ipso‐Alkenylation with Carboxylic Acid: Access to Polysubstituted Aryl Ketones. Issue 18 (12th August 2020)

• Record Type: Journal Article
• Authors: Yang, Shimin; Feng, Yunxia; Zhao, Shen; Chen, Lei; Li, Xinjin; Zhang, Daopeng; Liu, Hui; Dong, Yunhui; Sun, Feng‐Gang
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 18(2020)
• Page Start: 3919
• Page End: 3923
• Publication Date: 2020-08-12
• Subjects: palladium/norbornene -- ortho-acylation -- aryl ketones -- DCC -- carboxylic acids; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000799
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Herein a palladium/norbornene‐catalyzed sequential ortho ‐acylation and ispo ‐alkenylation for access to polysubstituted aryl ketones has been developed. By exploiting dicyclohexylcarbodiimide (DCC) as activator, aryl with electron‐donating or electron‐withdrawing functionalities, alkyl, and heteroaryl carboxylic acids were compatible in this transformation, affording the desired products in decent to good yields. Abstract :