Accessing 1, 8‐Naphthyridones by Metal‐Free Regioselective Amination of Pyridine N‐oxides/Acid‐Mediated Cyclization. Issue 18 (24th August 2020)

• Record Type: Journal Article
• Authors: Zhao, Lianbo; Hao, Lei; Fu, Yupeng; Cheng, Yan; Pan, Guojun; Désaubry, Laurent; Yu, Peng; Wang, Dong
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 18(2020)
• Page Start: 3841
• Page End: 3845
• Publication Date: 2020-08-24
• Subjects: Nitrogen heterocycles -- Synthetic methods -- Amine N-oxides -- Amination -- Naphthyridone; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000769
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A concise and practical method for the metal‐free synthesis of 1, 8‐naphthyridones is described using a two‐step approach involving regioselective amination of pyridine N ‐oxides and acid‐mediated cyclization. This is the first synthesis of 1, 8‐naphthyridones utilizing easily accessible pyridine N ‐oxides as substrates. Compared to previous reports, this method benefits from simple operation, easy access to starting materials, and a wide substrate scope, providing a variety of novel 1, 8‐naphthyridones. Abstract :