Biodegradable polyurethane/graphene oxide scaffolds for soft tissue engineering: in vivo behavior assessment. Issue 17 (21st November 2020)

• Record Type: Journal Article
• Authors: Ivanoska-Dacikj, Aleksandra; Bogoeva-Gaceva, Gordana; Krumme, Andres; Tarasova, Elvira; Scalera, Chiara; Stojkovski, Velimir; Gjorgoski, Icko; Ristoski, Trpe
• Is Part Of: International journal of polymeric materials. Volume 69:Issue 17(2020)
• Page Start: 1101
• Page End: 1111
• Publication Date: 2020-11-21
• Subjects: Biodegradable scaffolds -- biocompatibility -- biodegradable polyurethane -- electrospinning; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2019.1655754
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: In this work, 3D porous electrospun scaffolds based on DegraPol ® (DP), a polyester urethane, with different concentrations of graphene oxide (GO) (0.0–2.0 wt%) were obtained. In order to produce scaffolds with increased porosity, solutions of DP and GO were co-electrospun with polyethylene oxide (PEO), which was subsequently removed. The electrospinning resulted in the formation of porous and fibrous scaffolds with superior elasticity. The colloidal Ag was successfully used as a novel method of scaffold sterilization. The results of the in vivo analysis showed scaffold degradation, absence of an inflammatory process and penetration of tissue cells in the scaffold. GRAPHICAL ABSTRACT: