Preparation of calcium phosphate/carboxymethylcellulose-based bone cements. Issue 3 (9th September 2020)

• Record Type: Journal Article
• Authors: Güben, Esra; Arıcı, Şule; Bayır, Dilara; Bozdağ, Ergün; Ege, Duygu
• Is Part Of: Bioinspired, biomimetic and nanobiomaterials. Volume 9:Issue 3(2020)
• Page Start: 155
• Page End: 163
• Publication Date: 2020-09-09
• Subjects: biomaterials -- bone -- composites; Biomimetic materials -- Periodicals; Nanobiotechnology -- Periodicals; Biotechnology -- Periodicals; 660.605
• DOI: 10.1680/jbibn.19.00053
• Languages: English
• ISSNs: 2045-9858

Abstract

Abstract : In this study, novel bone substitutes were prepared based on a powder phase composed of tetracalcium phosphate, dicalcium phosphate dihydrate and calcium sulfate dihydrate and a liquid phase composed of carboxymethylcellulose (CMC), citric acid and gelatin. Samples were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), mechanical testing, swelling–degradation studies and cell culture studies. FTIR results showed that CMC and calcium phosphate interacted through electrostatic forces and hydrogen bonding. After incubation in phosphate-buffered saline for 28 days, hydroxyapatite formation was distinguished by way of SEM and XRD analysis. Mechanical test results revealed that the compressive modulus was up to 1.050 ± 0.071 GPa and that the compressive strength was up to 1.680 ± 0.023 MPa. Cell culture studies indicated that the samples were biocompatible and may be suitable for replacing cancellous bone and supporting new bone formation.