TMSOTf-catalyzed synthesis of substituted quinazolines using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions. Issue 36 (9th September 2020)

• Record Type: Journal Article
• Authors: Chan, Chieh-Kai; Lai, Chien-Yu; Wang, Cheng-Chung
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 36(2020)
• Page Start: 7201
• Page End: 7212
• Publication Date: 2020-09-09
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01507e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient synthetic route for the synthesis of substituted quinazolines under neat, metal-free and microwave irradiation conditions has been developed by using TMSOTf as an acid catalyst and HMDS as a nitrogen source. Abstract : In this article, we report an efficient and mild synthetic route for the construction of substituted quinazolines from functionalized 2-aminobenzophenones with various benzaldehydes using cat . TMSOTf and hexamethyldisilazane (HMDS) under neat, metal-free and microwave irradiation conditions in which gaseous ammonia was formed in situ . This synthetic protocol provided the desired quinazolines with a broad substrate scope in good to excellent yields. Some structures were confirmed by X-ray single-crystal diffraction analysis.