Stimuli-responsive poly(ionic liquid) nanoparticles for controlled drug delivery. Issue 35 (6th August 2020)

• Record Type: Journal Article
• Authors: Lu, Beibei; Zhou, Gaoxin; Xiao, Fan; He, Qianjun; Zhang, Jiaheng
• Is Part Of: Journal of materials chemistry. Volume 8:Issue 35(2020)
• Page Start: 7994
• Page End: 8001
• Publication Date: 2020-08-06
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d0tb01352h
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A novel poly(ionic liquid) (PIL)-based block copolymer, which can self-assemble into spherical nanoparticles, high drug loading content, and good ability to inhibit tumors. Therefore, this copolymer shows great potential for drug delivery. Abstract : A poly(ionic liquid) (PIL) obtained by polymerizing an ionic liquid (IL) monomer exhibits the characteristics of low cost and good biocompatibility, and it retains the excellent properties of the monomer. However, there is still a need to develop PILs for biomedical applications, which has been paid little attention. Herein, an amphiphilic block polymer containing a PIL block is synthesized, which simultaneously includes a targeted ligand, a photo-responsive block, and a pH-responsive block. The resultant amphiphilic block polymer can self-assemble into drug-loaded nanoparticles with a size of ∼80 nm in aqueous solution, and its drug loading capacity is as high as 70%. Moreover, the drug releasing mechanism of these drug-loaded nanoparticles can be triggered by light and pH stimuli. These novel amphiphilic PIL-based drug-loaded nanoparticles show highly effective antitumor effects, providing a promising approach for the delivery and controlled release of chemotherapy drugs in cancer therapy.