DOX sensitized upconversion metal–organic frameworks for the pH responsive release and real-time detection of doxorubicin hydrochloride. Issue 56 (14th September 2020)

• Record Type: Journal Article
• Authors: Tian, Feng; Xu, Chen; Xu, Mingyue; Gao, Haiqing; Xiao, Ziyi; Li, Ling; Wang, Yingxi
• Is Part Of: RSC advances. Volume 10:Issue 56(2020)
• Page Start: 33894
• Page End: 33902
• Publication Date: 2020-09-14
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra06417c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Drug resistance is a major obstacle in cancer treatment, and designing a material that monitors real-time drug release remains a top priority. Abstract : Drug resistance is a major obstacle in cancer treatment, and designing a material that monitors real-time drug release remains a top priority. In this study, metal–organic frameworks doped with lanthanum and thulium were synthesized and then coated with aminated silica to form La/Tm-MOF@d-SiO2 as a drug carrier. Doxorubicin hydrochloride (DOX) was selected as a drug model, and the drug loading and release were investigated. It was found that the release of DOX under acidic conditions reached an optimal level, indicating the pH-responsiveness of La/Tm-MOF@d-SiO2 . Under acidic conditions (pH = 5.8), upconversion fluorescence was generated after loading DOX on La/Tm-MOF@d-SiO2 . At pH = 5.8, the longer the drug released, the stronger the upconversion fluorescence. It was found that the upconversion fluorescence intensity is directly proportional to the amount of drug released; thus, the real-time monitoring of DOX release in tumor cells can be performed based on the upconversion fluorescence.