Iron-catalyzed radical cascade 6-endo cyclization of dienes towards fused nitrogen heterocycles initiated by an alkoxycarbonyl radical. Issue 36 (10th September 2020)

• Record Type: Journal Article
• Authors: Qiao, Shanshan; Qian, Peng-Cheng; Chen, Fan; Cheng, Jiang
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 36(2020)
• Page Start: 7086
• Page End: 7089
• Publication Date: 2020-09-10
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01438a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An iron-catalyzed radical cascade cyclization of dienes initiated by an alkoxycarbonyl radical has been developed in the presence of (NH4 )2 S2 O8, leading to a series of fused nitrogen heterocyclic compounds under relatively mild reaction conditions. Abstract : An iron-catalyzed radical cascade cyclization of dienes initiated by an alkoxycarbonyl radical has been developed in the presence of (NH4 )2 S2 O8, leading to a series of fused nitrogen heterocyclic compounds under relatively mild reaction conditions. The reaction is triggered by the addition of an alkyoxycarbonyl radical derived from the cleavage of alkoxyformyl hydrazide. Afterward, the formed nucleophilic radical preferred addition to the electron-neutral vinyl rather than the electron-deficient vinyl, followed by cascade 6- endo cyclization and further radical cyclization.