Copper-catalyzed cross-coupling and sequential allene-mediated cyclization for the synthesis of 1, 2, 3-triazolo[1, 5-a]quinolines. Issue 36 (8th September 2020)

• Record Type: Journal Article
• Authors: Yang, Jianhua; Xiong, Shaoqi; Ren, Yongsheng; Xiao, Tiebo; Jiang, Yubo
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 36(2020)
• Page Start: 7174
• Page End: 7182
• Publication Date: 2020-09-08
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob00435a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : In this paper, a tandem reaction involving copper-catalyzed cross-coupling and allene-mediated cyclization of 1-(2-ethynylaryl)-1, 4-disubstituted-1, 2, 3-triazole with N -tosylhydrazone has been developed. Abstract : In this paper, a tandem reaction involving copper-catalyzed cross-coupling and allene-mediated cyclization of 1-(2-ethynylaryl)-1, 4-disubstituted-1, 2, 3-triazole with N -tosylhydrazone has been developed. This method features operational simplicity, excellent functional group compatibility, broad substrate scope, and easily available feedstock, providing an efficient and practical strategy for the synthesis of highly functionalized 1, 2, 3-triazolo[1, 5- a ]quinolines.