Avobenzone incorporation in a diverse range of Ru(ii) scaffolds produces potent potential antineoplastic agents. Issue 35 (26th August 2020)

• Record Type: Journal Article
• Authors: Ryan, Raphael T.; Havrylyuk, Dmytro; Stevens, Kimberly C.; Moore, L. Henry; Kim, Doo Young; Blackburn, Jessica S.; Heidary, David K.; Selegue, John P.; Glazer, Edith C.
• Is Part Of: Dalton transactions. Volume 49:Issue 35(2020)
• Page Start: 12161
• Page End: 12167
• Publication Date: 2020-08-26
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d0dt02016h
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Abstract : Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.