Copper-catalyzed aerobic oxidative C–C bond cleavage of simple ketones for the synthesis of amides. Issue 35 (7th September 2020)

• Record Type: Journal Article
• Authors: Yang, Guo-Ping; Li, Ke; Liu, Wei; Zeng, Kai; Liu, Yu-Feng
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 35(2020)
• Page Start: 6958
• Page End: 6964
• Publication Date: 2020-09-07
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01601b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A practical approach to amides via C–C bond cleavage has been developed. A number of simple ketones could be converted to amides with simple amines. Abstract : A Cu-catalyzed oxidative amidation of simple ketones with amines via carbon–carbon (C–C) bond cleavage has been developed. A number of aryl and alkyl ketones could be easily converted to amides using cheap copper salt as the catalyst and O2 as the oxidant with a wide range of amines, including primary and secondary amines. This method shows a notable advantage of the broad scope for the substrate, thus providing a practical approach to amides. A plausible mechanism is proposed based on the preliminary experiments.