Analgesic Mechanism of Sinomenine against Chronic Pain. (6th May 2020)

• Record Type: Journal Article
• Authors: Jiang, Wei; Fan, Weiming; Gao, Tianle; Li, Tao; Yin, Zhenming; Guo, Huihui; Wang, Lulu; Han, Yanxing; Jiang, Jian-Dong
• Other Names: Aloisi Anna Maria Academic Editor.
• Is Part Of: Pain research and management. Volume 2020(2020)
• Publication Date: 2020-05-06
• Subjects: Pain -- Periodicals; Pain -- Treatment -- Periodicals; 616.0472
• DOI: 10.1155/2020/1876862
• Languages: English
• ISSNs: 1203-6765

Abstract

Abstract : Purified from the roots of the plant Sinomenium acutum, sinomenine is traditionally used in China and Japan for treating rheumatism and arthritis. Previously, we have demonstrated that sinomenine possessed a broad analgesic spectrum in various chronic pain animal models and repeated administration of sinomenine did not generate tolerance. In this review article, we discussed sinomenine's analgesic mechanism with focus on its role on immune regulation and neuroimmune interaction. Sinomenine has distinct immunoregulative properties, in which glutamate, adenosine triphosphate, nitric oxide, and proinflammatory cytokines are thought to be involved. Sinomenine may alter the unbalanced neuroimmune interaction and inhibit neuroinflammation, oxidative stress, and central sensitization in chronic pain states. In conclusion, sinomenine has promising potential for chronic pain management in different clinical settings.