CD7-Positive Diffuse Large B-Cell Lymphoma Presenting as an Intranasal Tumor. (13th April 2020)

• Record Type: Journal Article
• Authors: Teshima, Kazuaki; Kume, Masaaki; Kawaharada, Yasushi; Saito, Takashi; Abe, Ko; Ikeda, Sho; Ohyagi, Hideaki; Zuguchi, Megumi; Zuguchi, Masashi; Kubota, Yosuke; Enomoto, Yoshitaka; Miura, Masahito; Takahashi, Satsuki; Saito, Masahiro; Saito, Ken; Takahashi, Naoto
• Other Names: Ohno Tatsuharu Academic Editor.
• Is Part Of: Case reports in hematology. Volume 2020(2020)
• Publication Date: 2020-04-13
• Subjects: Hematology -- Periodicals; Hematology -- Case studies -- Periodicals; Blood -- Diseases -- Periodicals; Hematology; Hematologic Diseases; Blood -- Diseases; Hematology; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.15
• DOI: 10.1155/2020/1514729
• Languages: English
• ISSNs: 2090-6560

Abstract

Abstract : We report a case of a 74-year-old man with a cluster of differentiation (CD) 7-positive diffuse large B-cell lymphoma (DLBCL) in the right nasal cavity. Flow cytometry analyses showed CD7 and CD20 positivity in tumor cells. The patient received 6 cycles of R-CHOP plus local radiation therapy because positron emission tomography-computed tomography after R-CHOP revealed an intranasal lesion. The patient achieved complete remission (CR) after radiation therapy. The frequency of CD7-positive DLBCL is rare, and only 11 cases with follow-up of clinical course have been reported thus far. CR or partial response was noted in 8 of 11 cases after receiving rituximab combined with chemotherapy. In total, 9 of 12 cases involved the development of extranodal lesions, which occurred as an intranasal tumor in 3 cases. It is important to examine the clinical features by accumulation of further cases.